A chiral beta,delta-dioxo-epsilon-sulfinyl ester in a convergent enantioselective synthesis towards the C-1-C-13 polyol fragment of amphotericin B

Authors
Solladie, G Wilb, N Bauder, C
Citation
G. Solladie et al., A chiral beta,delta-dioxo-epsilon-sulfinyl ester in a convergent enantioselective synthesis towards the C-1-C-13 polyol fragment of amphotericin B, EUR J ORG C, (11), 1999, pp. 3021-3026
Citations number
40
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
1434193X → ACNP
Issue
11
Year of publication
1999
Pages
3021 - 3026
Database
ISI
SICI code
1434-193X(199911):11<3021:ACBEIA>2.0.ZU;2-5
Abstract
This paper describes an efficient stereocontrolled and convergent approach towards the C-1-C-13 polyol fragment of amphotericin B. The strategy is bas ed on the stereoselective reduction of a chiral beta,gamma-dioxo-epsilon-su lfinyl ester to obtain anti- or syn-1,3-diols.