Induced fit selection of a barbiturate receptor from a dynamic structural and conformational/configurational library

Authors
Berl, V Huc, I Lehn, JM DeCian, A Fischer, J
Citation
V. Berl et al., Induced fit selection of a barbiturate receptor from a dynamic structural and conformational/configurational library, EUR J ORG C, (11), 1999, pp. 3089-3094
Citations number
26
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
1434193X → ACNP
Issue
11
Year of publication
1999
Pages
3089 - 3094
Database
ISI
SICI code
1434-193X(199911):11<3089:IFSOAB>2.0.ZU;2-V
Abstract
The selection of the receptor presenting the strongest affinity for a barbi turate substrate from a dynamic combinatorial library of constituents diffe ring in structure and conformation/configuration is described. The gradual addition of the barbiturate to an equilibrating mixture of hydrazone isomer s leads to the quantitative shift towards a single species, 3, which presen ts highest complementarity to the substrate and yields the supramolecular e ntity 3:4.