Assessment of risk for chromosomal abnormalities at 10-14 weeks of gestation by nuchal translucency and maternal age in 5,210 fetuses at a single centre
Ma. Zoppi et al., Assessment of risk for chromosomal abnormalities at 10-14 weeks of gestation by nuchal translucency and maternal age in 5,210 fetuses at a single centre, FETAL DIAGN, 15(3), 2000, pp. 170-173
Objective: To evaluate the screening of chromosomal abnormalities by nuchal
translucency (NT) measurement. Methods: Assessment of risk for chromosomal
abnormalities by NT and maternal age in 5,210 single fetuses with karyotyp
e and outcome already known. Results: Risk was greater than or equal to 1 i
n 300 in 640 (12.2%) of all fetuses, in 575 (11.1%) of the normal fetuses,
in 38 (80.8%) of the fetuses affected by trisomy 21, and in 65 (89%) of the
fetuses affected by chromosomal abnormalities. Risk was greater than or eq
ual to 1 in 200 in 477 (9.1%) of all fetuses, in 418 (8.1%) of the normal f
etuses, in 35 (74.4%) of the fetuses affected by trisomy 21, and in 59 (80.
8%) of the fetuses affected by chromosomal abnormalities. Risk was greater
than or equal to 1 in 100 in 270 (5.1%) of all fetuses, in 216 (4.2%) of th
e normal fetuses, in 33 (70.2%) of the fetuses affected by trisomy 21, and
in 54 (73.9%) of the fetuses affected by chromosomal abnormalities. Conclus
ions: Risk generated by NT and maternal age is effective in screening for c
hromosomal abnormalities. Copyright (C) 2000 S. Karger AG. Basel.