Assessment of risk for chromosomal abnormalities at 10-14 weeks of gestation by nuchal translucency and maternal age in 5,210 fetuses at a single centre

Citation
Ma. Zoppi et al., Assessment of risk for chromosomal abnormalities at 10-14 weeks of gestation by nuchal translucency and maternal age in 5,210 fetuses at a single centre, FETAL DIAGN, 15(3), 2000, pp. 170-173
Citations number
20
Categorie Soggetti
Reproductive Medicine
Journal title
FETAL DIAGNOSIS AND THERAPY
ISSN journal
10153837 → ACNP
Volume
15
Issue
3
Year of publication
2000
Pages
170 - 173
Database
ISI
SICI code
1015-3837(200005/06)15:3<170:AORFCA>2.0.ZU;2-7
Abstract
Objective: To evaluate the screening of chromosomal abnormalities by nuchal translucency (NT) measurement. Methods: Assessment of risk for chromosomal abnormalities by NT and maternal age in 5,210 single fetuses with karyotyp e and outcome already known. Results: Risk was greater than or equal to 1 i n 300 in 640 (12.2%) of all fetuses, in 575 (11.1%) of the normal fetuses, in 38 (80.8%) of the fetuses affected by trisomy 21, and in 65 (89%) of the fetuses affected by chromosomal abnormalities. Risk was greater than or eq ual to 1 in 200 in 477 (9.1%) of all fetuses, in 418 (8.1%) of the normal f etuses, in 35 (74.4%) of the fetuses affected by trisomy 21, and in 59 (80. 8%) of the fetuses affected by chromosomal abnormalities. Risk was greater than or equal to 1 in 100 in 270 (5.1%) of all fetuses, in 216 (4.2%) of th e normal fetuses, in 33 (70.2%) of the fetuses affected by trisomy 21, and in 54 (73.9%) of the fetuses affected by chromosomal abnormalities. Conclus ions: Risk generated by NT and maternal age is effective in screening for c hromosomal abnormalities. Copyright (C) 2000 S. Karger AG. Basel.