The Mediterranean diet is reputed to account for the lower incidence of cor
onary heart disease (CHD) in southern Europe. Olive oil is the principal so
urce of fat in the Mediterranean diet, therefore the southern European diet
contains more monounsaturated fatty acids (MUFA) and less saturated fatty
acids (SFA), compared to the Northern European diet. Atherosclerosis and th
rombosis are the two key pathophysiological processes which lead to the dev
elopment of CHD. Therefore, the aim of the EU project entitled "The Benefic
ial Properties of Olive Oil" was to investigate how olive oil mediated its
protective effect against CHD. The project had two parts, phase I involved
a cross-cultural comparison to investigate the effect of a habitual souther
n European diet which is rich in olive oil compared to the northern europea
n diet which contains little or no olive oil on a range of CHD risk factors
. In phase II, a dietary intervention study was designed to substitute diet
ary SFA with MUFA, derived from olive oil, in the usual diet of free-living
northern European men to investigate if this dietary change affected indic
es of CHD risk. (C) 2000 Elsevier Science Ltd. All rights reserved.