PHARMACOKINETIC AND TUMOR STUDIES OF ALOIN (A NATURAL ANTHRAQUINONE) ON MICE BEARING SOLID EHRLICH CARCINOMA

Authors
FAHIM FA ESMAT AY MADY EA AMIN MA
Citation
Fa. Fahim et al., PHARMACOKINETIC AND TUMOR STUDIES OF ALOIN (A NATURAL ANTHRAQUINONE) ON MICE BEARING SOLID EHRLICH CARCINOMA, Journal of tumor marker oncology, 12(2), 1997, pp. 127-134
Citations number
18
Categorie Soggetti
Oncology,"Biothechnology & Applied Migrobiology
Journal title
Journal of tumor marker oncology → ACNP
ISSN journal
08863849
Volume
12
Issue
2
Year of publication
1997
Pages
127 - 134
Database
ISI
SICI code
0886-3849(1997)12:2<127:PATSOA>2.0.ZU;2-9
Abstract
Acute lethal (LD100) and median lethal (LD50) values of aloin on i.m. administration using mice as experimental animals were found to be 440 and 260 mg/kg b. w., respectively. Maximum tolerated dose (MTD) was c alculated as 50 mg./kg. b. w. Treatment of solid Ehrlich carcinoma-bea ring mice with the MTD of aloin every other day showed an increase of 230% in the life span of the tumoured animals, inhibition of tumour gr owth rate (T/C%) of 25%, and tumour growth delay time (T-C) of 19 days , compared to untreated tumoured controls. The drug efficacy for aloin on solid tumour regression was 36%.