Germline BRCA2 mutation in a patient with fallopian tube carcinoma: A casereport

Objectives. Fallopian tube carcinoma is similar to ovarian and peritoneal c arcinoma with respect to histology, response to chemotherapy, and prognosis . BRCA germline mutations have been commonly reported in ovarian and perito neal carcinoma but rarely in other gynecologic cancers. Methods. A patient with fallopian tube carcinoma and a family history of ov arian carcinoma underwent genetic counseling and BRCA testing as did her da ughter. Results. The patient and her daughter were found to have a germline BRCA2 m utation. Conclusion. Like a family history of ovarian or peritoneal carcinoma, the o ccurrence of fallopian tube cancer should alert the clinician to the possib ility of an abnormality in the breast cancer susceptibility 1 or 2 genes. ( C) 2000 Academic Press.