Lymphoid blastic crisis in Philadelphia chromosome-positive chronic granulocytic leukemia following high-grade non-Hodgkin's lymphoma. A case report and review of literature

In this paper we describe a case of a 65-year old man with a lymphoid blast ic crisis of a chronic granulocytic leukemia occurring seven years after a palatine tonsillar non-Hodgkin's lymphoma treated with chemotherapy and rad iation therapy. Bone marrow cytogenetic study demonstrated the presence of the typical t(9;22)(q34;q11) and the molecular biology study showed the p21 0 rearrangement (b2a2). The patient died within a few months, unresponsive to any treatment. This Is the first case,;described in literature, of a sec ondary chronic granulocytic leukemia onset with a lymphoid blastic crisis. The authors report the case and a literature review. (C) 2000, Ferrata Storti Foundation.