A comprehensive review of vitamin K and vitamin K antagonists

Vitamin K-dependent proteins are known to play an important role in the reg ulation of blood coagulation, bone metabolism, and vascular biology. Becaus e the vitamin K requirement of bone and vessel wall is higher than that of the liver (where the clotting factors are produced), recommended daily allo wance values for K vitamins have to be redefined. Low vitamin K intake may be a risk factor for bone fracture and cardiovascular disease in later life .