No correlation of polymorphism of angiotensin-converting enzyme genes withleft ventricular hypertrophy in essential hypertension

To investigate the correlation of polymorphism of angiotensin-converting en zyme(ACE) genes with left ventricular hypertrophy in essential hypertension , 151 patients with essential hypertension were studied. ACE genotypes were determined by PCR technology and diastolic left ventricular diameter (DLVd ), systolic left ventricular diameter(SLVd), interseptal Ventricular thickn ess(IVS), and left ventricular posterior wall thickness (LVPW) were scanned by echocardiography. Left ventricular mass (LVM) and the left ventricular mass index (LVMI) were calculated from echocardiographic findings. Results revealed that DLVd, SLVd, IVS, LVPW, LVM, and LVMI of the DD genotype group were 49.9 +/- 5.6 mm, 30.5 +/- 6.5 mm, 11.2 +/- 1.6 mm, 11.7 +/- 1.5 mm, 2 59.5 +/- 62.1 g, 92.7 +/- 23.5 g/m(2), respectively. DLVd, SLVd, IVS, LVPW, LVM, and LVMI of the ID genotype group were 8.9 +/- 5.3 mm, 31.5 +/- 5.2 m m, 11.4 +/- 1.7 mm, 11.9 +/- 1.6 mm, 261.3 +/- 70.3 g, and 94.9 +/- 25.8 g/ m(2), respectively, and DLVd, SLVd, IVS, LVPW, LVM, and LVMI of the ii geno type group are 48.9 +/- 5.5 mm, 31.8 +/- 6.5 mm, 11.1 +/- 1.9 mm, 11.5 +/- 1.8 mm, 250.8 +/- 82.5 g and 90.8 +/- 30.1 g/m(2) respectively. There was n o significant difference between the ID, DD and tl genotype groups as regar ds DLVd, SLVd, IVS, LVPW, LVM, and LVMI (p>0.05). These findings indicate t hat there is no association between the ACE gene and left ventricular hyper trophy in essential hypertension occurring in the Chinese population.