Tumor regression by inductive hyperthermia combined with hepatic embolization using dextran magnetite-incorporated microspheres in rats

We formulated a novel preparation of microspheres incorporating dextran mag netite complex (DM-MS), which enable magnetic field-induced heating for the induction of hyperthermia. Using a 500 kHz magnetic field combined with ar teriolar embolization of DM-MS, inductive hyperthermia was performed for th e treatment of liver tumors in rats. Three days after treatment, the percen tage increase of tumor volume in the embolo-hyperthermia, embolization alon e, and control groups were 28%, 124%, and 385%, respectively, with the embo lo-hyperthermia group differing significantly from the remaining groups. Th is study demonstrated the feasibility of combining embolization of DM-MS wi th hyperthermia as an antitumor therapy.