Volatile nitrites (amyl and butyl) are popular recreational drugs, especial
ly in the homosexual population. Haemolytic anaemia is a rare complication
of nitrite inhalation and occurs when the reducing capacity of the red cell
enzymes is overcome by the oxidizing effect of the nitrite. We describe he
re a patient with HIV infection who developed a profound haemolytic anaemia
after repeated inhalation of large quantities of amyl nitrite.