A CRYSTAL MILESTONE - THE STRUCTURE OF REGULATED SRC

Citation
G. Supertifurga et S. Gonfloni, A CRYSTAL MILESTONE - THE STRUCTURE OF REGULATED SRC, BioEssays, 19(6), 1997, pp. 447-450
Citations number
31
Categorie Soggetti
Biology,Biology
Journal title
ISSN journal
02659247
Volume
19
Issue
6
Year of publication
1997
Pages
447 - 450
Database
ISI
SICI code
0265-9247(1997)19:6<447:ACM-TS>2.0.ZU;2-9
Abstract
The viral and cellular forms of the Src protein tyrosine kinases take a prototypic role in oncology and signal transduction research, by vir tue of being holders of an impressive number of 'firsts'. Our understa nding of the biochemistry and physiology of Src has therefore always b een used as a reference for our general advancement in the field of pr otein phosphorylation and growth control. The recent solution of the c rystal structure of two members of the Src family((1,2)) represents a milestone in these disciplines and, as usual, provides a general looko ut post for developments to come.