Zafirlukast in clinical practice - Results of the Accolate Clinical Experience and Pharmacoepidemiology Trial (ACCEPT) in patients with asthma

Citation
Jp. Kemp et al., Zafirlukast in clinical practice - Results of the Accolate Clinical Experience and Pharmacoepidemiology Trial (ACCEPT) in patients with asthma, J FAM PRACT, 48(6), 1999, pp. 425-432
Citations number
20
Categorie Soggetti
General & Internal Medicine
Journal title
JOURNAL OF FAMILY PRACTICE
ISSN journal
00943509 → ACNP
Volume
48
Issue
6
Year of publication
1999
Pages
425 - 432
Database
ISI
SICI code
0094-3509(199906)48:6<425:ZICP-R>2.0.ZU;2-C
Abstract
BACKGROUND. Zafirlukast is an oral leukotriene receptor antagonist used in the treatment of patients with mild to moderate asthma. To investigate its effects in a clinical practice setting, we evaluated zafirlukast in a heter ogeneous group of patients who had asthma of different degrees of severity and who were receiving concomitant asthma medications. METHODS. A total of 3759 patients were enrolled at 924 sites. Patients rece ived zafirlukast 20 mg twice a day for 4 weeks. Pulmonary function was meas ured twice a day, and overall asthma symptom scores, number of nighttime aw akenings, severity of morning asthma symptoms, and beta(2)-agonist use were recorded daily. RESULTS. In the efficacy analysis (3207 evaluable patients), all parameters showed statistically significant improvement that continued throughout the 4 weeks of the trial. A total of 71% of patients had improved pulmonary fu nction and 72% had improved asthma symptoms. Improvement was consistent reg ardless of asthma severity category and regardless of concomitant asthma me dication category. More than 70% of both physicians and patients indicated there was clinical improvement in pulmonary measures as well as in asthma s ymptoms. Common adverse events reported were headache (3.7%), nausea (1.4%) , pharyngitis (1.4%), and sinusitis (1.1%). CONCLUSIONS. Zafirlukast 20 mg twice a day is well tolerated and improves p ulmonary function and asthma symptoms, regardless of asthma severity catego ry and regardless of concomitant asthma medication category.