Synthesis of N-quaternary ammonium [H-3] and [Tc-99m]polyazamacrocycles, potential radiotracers for cartilage imaging

Authors
Nicolas, C Borel, M Maurizis, JC Gallais, N Rapp, M Ollier, M Verny, M Madelmont, JC
Citation
C. Nicolas et al., Synthesis of N-quaternary ammonium [H-3] and [Tc-99m]polyazamacrocycles, potential radiotracers for cartilage imaging, J LABEL C R, 43(6), 2000, pp. 585-594
Citations number
6
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
43
Issue
6
Year of publication
2000
Pages
585 - 594
Database
ISI
SICI code
0362-4803(200005)43:6<585:SONA[A>2.0.ZU;2-P
Abstract
The [H-3] and [Tc-99m] synthesis of three new compounds, N-[3-(pyridinio)pr opyl] cyclam (NPPC), N-[3-(triethylammonium)propyl] cyclam (NTPC) and N-[3- (triethylammonium)propyl]-15ane-N5 (NTP 15-5), potential tracers for cartil age, is reported. NPPC and NTPC were labelled with tritium on the ethyl gro up of cyclam with a specific radioactivity of 89 MBq/mmol. The [Tc-99m]-lab elling of the three quaternary ammonium chelates was realized with a high s pecific activity in the range 20-25 MBq/mu mol.