Synthesis of 1-benzyl-4-[(5,[C-11]6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine: a promising ligand for visualisation of acetylcholine esterase by PET

Authors
De Vos, F Santens, P Slegers, G Vermeirsch, H Dierckx, RA De Reuck, J
Citation
F. De Vos et al., Synthesis of 1-benzyl-4-[(5,[C-11]6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine: a promising ligand for visualisation of acetylcholine esterase by PET, J LABEL C R, 43(6), 2000, pp. 595-601
Citations number
21
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
43
Issue
6
Year of publication
2000
Pages
595 - 601
Database
ISI
SICI code
0362-4803(200005)43:6<595:SO1>2.0.ZU;2-V
Abstract
Donepezil (1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl-]piperidine), a potent acetylcholine esterase inhibitor, was labelled with [C-11]iodometh ane by O-methylation of the O-6'-desmethyl precursor. Synthesis, purificati on and formulation were performed in approximately 30 min with an average s pecific activity of 39.5 GBq/mu mol at EOS. The total activity available fo r applications was 7.5-11.1 GBq.