Synthesis of 6-dimethylamino-9-[3 '-(O-methyl) (2S)-[UL-C-14]-tyrosinylamino)-3 '-deoxy-beta-D-ribofuranosyl] purine

Authors
Mehrotra, AP Ryan, MD Gani, D
Citation
Ap. Mehrotra et al., Synthesis of 6-dimethylamino-9-[3 '-(O-methyl) (2S)-[UL-C-14]-tyrosinylamino)-3 '-deoxy-beta-D-ribofuranosyl] purine, J LABEL C R, 43(6), 2000, pp. 623-634
Citations number
23
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
43
Issue
6
Year of publication
2000
Pages
623 - 634
Database
ISI
SICI code
0362-4803(200005)43:6<623:SO6'(>2.0.ZU;2-T
Abstract
In order to investigate and further refine the mechanism of the unique clea vage activity of the 18 amino acid 2A region of the foot-and-mouth-disease virus (FMDV), the synthesis of C-14-labelled puromycin is required. Puromyc in is an inhibitor of protein synthesis and is an analogue of the terminal aminoacyl-adenosine portion of aminoacyl-tRNA. A short and expedient four s tep synthesis of 6-dimethylamino-9-[3'-(O-methyl) (2S)-[UL-C-14]tyrosinylam ino)-3'-deoxy-beta-D-ribofuranosyl] purine (C-14-labelled puromycin) starti ng from (2S)-[UL-C-14]-tyrosine is therefore described.