INTRAVENOUS ANESTHETICS - SOME CELLULAR SITES OF ACTION

Authors
DZOLJIC M GELB AW
Citation
M. Dzoljic et Aw. Gelb, INTRAVENOUS ANESTHETICS - SOME CELLULAR SITES OF ACTION, European journal of anaesthesiology, 14, 1997, pp. 3-7
Citations number
50
Categorie Soggetti
Anesthesiology
Journal title
European journal of anaesthesiology → ACNP
ISSN journal
02650215
Volume
14
Year of publication
1997
Supplement
15
Pages
3 - 7
Database
ISI
SICI code
0265-0215(1997)14:<3:IA-SCS>2.0.ZU;2-P
Abstract
Intravenous anaesthetics have diverse effects on neurones within the c entral nervous system. Only those that occur at clinical concentration s are likely to be relevant. The dominant effect of many agents is the potentiation of the inhibitory neurotransmitter gamma amino butyric a cid (GABA) by various mechanisms while inhibiting the effects of excit atory transmitters seems to be less dominant, except for ketamine.