Scyllo-inositol in post-mortem brain of bipolar, unipolar and schizophrenic patients

Inositol levels measured in postmortem brain of unipolar, bipolar and schiz ophrenic patients, suicide victims and normal controls showed no difference in scyllo-inositol levels in frontal or occipital cortex between any of th e groups. We could not replicate previous reports of low myo-inositol level s in the frontal cortex of unipolar, bipolar and schizophrenic patients and suicide victims. There was no correlation between myo-inositol levels and estimated chlorpromazine equivalents in neuroleptic-treated subjects, and n o effect of chronic haloperidol treatment on rat brain myo-inositol levels.