Solid phase synthesis of C-terminal peptide amides: Development of a new aminoethyl-polystyrene linker on the Multipin (TM) solid support

A new aminoethyl-polystyrene linker, stable at low concentrations of TFA, h as been developed for the solid phase synthesis of peptide amides. The desc ribed linker is stable under conditions which remove Bu-t protecting groups (30-50% TFA in DCM) and the desired product can be finally cleaved off the solid support in 95% TFA (5% H2O). Model peptide amides and other N-alkyla ted peptide amides have been successfully synthesized in good yield and pur ity. Copyright (C) 2000 European Peptide Society and John Wiley gr Sons, Lt d.