Treatment of chronic plaque-stage psoriasis and psoriatic arthritis with mycophenolate mofetil

Mycophenolate mofetil (MMF), a widely used immunosuppressant in organ trans plantation, is a recent addition to the therapeutic armamentarium of autoim mune and inflammatory skin disorders in dermatology. We describe 5 patients with moderate to severe chronic plaque psoriasis and 6 patients with psori atic arthritis that was refractory to conventional systemic and:or topical antipsoriatic treatment who were treated with MMF monotherapy (2 g/d) in a 10-week study. Although MMF was tolerated well in all patients, only patien ts with moderate psoriasis and psoriatic arthritis improved with therapy wh ereas patients with ses ere psoriasis did not respond to MMF. Although MMF seems to be effective and safe for blistering autoimmune diseases and pyode rma gangrenosum, our data do not allow optimistic statements on the use of MMF in severe plaque-stage psoriasis. However, MMF may develop into an inte resting therapeutic alternative for patients with psoriatic arthritis.