The behaviour of middle ear cholesteatoma appears to depend on the pathogen
esis and the specific location of its origin. As well as the classical acqu
ired form of cholesteatoma, we discuss subgroups such as the congenital for
m of the disease, posttraumatic and external meatal cholesteatomas. The imp
act that basic research has had on cholesteatoma surgery, the scientific kn
owledge of tissue interactions and controversies on the reuse of ossicles a
re presented and discussed. Available data on cholesteatoma epidemiology an
d the possible influence of tubal function will be considered. The basic pr
inciples of individualised cholesteatoma surgery are pointed out, specifica
lly the treatment of the posterior canal wall and the surgical options avai
lable depending on the site of predilection and the pneumatisation characte
ristics. In general, the most important surgical principle of following the
cholesteatoma epithelium is emphasised. Open-cavity surgery, treatment and
replacement of the ossicular chain, the most frequently occurring mistakes
and revision surgery are discussed. Complications such as exposed dura, la
byrinthine fistula, exposed facial nerve, sinus thrombosis, extradural absc
ess/subdural abscess, meningitis and brain abscess are presented. Specific
problem areas in cholesteatoma surgery such as surgery in the only hearing
ear or in the paediatric age group are also discussed.