A new twist for the tumour suppressor hamartin

Authors
Fukuhara, S Gutkind, JS
Citation
S. Fukuhara et Js. Gutkind, A new twist for the tumour suppressor hamartin, NAT CELL BI, 2(5), 2000, pp. E76-E78
Citations number
22
Categorie Soggetti
Cell & Developmental Biology
Journal title
NATURE CELL BIOLOGY
ISSN journal
14657392 → ACNP
Volume
2
Issue
5
Year of publication
2000
Pages
E76 - E78
Database
ISI
SICI code
1465-7392(200005)2:5<E76:ANTFTT>2.0.ZU;2-B
Abstract
Ezrin/radixin/moesin (ERM) proteins form crosslinks between cortical actin filaments and the plasma membrane. New findings indicate that they may also bind to the tumour-suppressor protein hamartin, thereby regulating Rho GTP ases, the actin-based skeleton and cell adhesion. Loss of hamartin function disrupts cell adhesion, which may contribute to the formation of tumours i n individuals carrying hamartin mutations.