EFFICIENT AND CONVENIENT PYRIDINE RING-E FORMATION OF THE CYTOTOXIC MARINE ALKALOID ASCIDIDEMIN AND RELATED ANALOGS

Authors
LINDSAY BS PEARCE AN COPP BR
Citation
Bs. Lindsay et al., EFFICIENT AND CONVENIENT PYRIDINE RING-E FORMATION OF THE CYTOTOXIC MARINE ALKALOID ASCIDIDEMIN AND RELATED ANALOGS, Synthetic communications, 27(15), 1997, pp. 2587-2592
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
27
Issue
15
Year of publication
1997
Pages
2587 - 2592
Database
ISI
SICI code
0039-7911(1997)27:15<2587:EACPRF>2.0.ZU;2-0
Abstract
Conversion of tetracyclic quinone 1 to the cytotoxic pentacyclic alkal oid ascididemin (2) in 80% yield is achieved by reaction with paraform aldehyde and ammonium chloride in refluxing acetic acid. High yielding annelations are also observed for the related analogues N-8 deaza asc ididemin (3) and kuanoniamine A (4).