Efficient palladium-catalyzed N-arylation of indoles

Authors
Old, DW Harris, MC Buchwald, SL
Citation
Dw. Old et al., Efficient palladium-catalyzed N-arylation of indoles, ORG LETT, 2(10), 2000, pp. 1403-1406
Citations number
18
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
10
Year of publication
2000
Pages
1403 - 1406
Database
ISI
SICI code
1523-7060(20000518)2:10<1403:EPNOI>2.0.ZU;2-4
Abstract
The N-arylation of indoles, including a variety of substituted ones, has be en carried out using bulky, electron rich phosphines as the supporting liga nd in combination with Pd-2(dba)(3). Using this catalyst system, the effici ent coupling of indole and a variety of substituted indoles with aryl iodid es, bromides, chlorides, and triflates can be achieved.