Palladium(0)-catalyzed cyclization reaction of polymer-supported aryl iodides with 1,2-allenyl carboxylic acids. A facile solid-phase synthesis of butenolides

Authors
Ma, SM Duan, DH Shi, ZJ
Citation
Sm. Ma et al., Palladium(0)-catalyzed cyclization reaction of polymer-supported aryl iodides with 1,2-allenyl carboxylic acids. A facile solid-phase synthesis of butenolides, ORG LETT, 2(10), 2000, pp. 1419-1422
Citations number
30
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
10
Year of publication
2000
Pages
1419 - 1422
Database
ISI
SICI code
1523-7060(20000518)2:10<1419:PCROPA>2.0.ZU;2-Z
Abstract
[GRAPHICS] Aryl iodides anchored to Merrifield resin via the linkages between a carbox yl, hydroxyl, or hydroxymethyl group and the benzylic chloride moiety in th e resin reacted efficiently with 1,2-allenic carboxylic acids under the cat alysis of Pd(0) to afford polymer-supported butenolides. Polysubstituted bu tenolides can be easily cleaved from the resins by Lewis acid-catalyzed pro cesses in good yields and purities.