REDUCTIVE CLEAVAGE OF TERT-BUTYLDIMETHYLSILYL ETHER VIA INTRAMOLECULAR TRANSFER OF HYDRIDE

Authors
SARAVANAN P GUPTA S DATTAGUPTA A GUPTA S SINGH VK
Citation
P. Saravanan et al., REDUCTIVE CLEAVAGE OF TERT-BUTYLDIMETHYLSILYL ETHER VIA INTRAMOLECULAR TRANSFER OF HYDRIDE, Synthetic communications, 27(15), 1997, pp. 2695-2699
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
27
Issue
15
Year of publication
1997
Pages
2695 - 2699
Database
ISI
SICI code
0039-7911(1997)27:15<2695:RCOTEV>2.0.ZU;2-V
Abstract
The cleavage of alpha-hydroxy tert-butyldimethylsilyl ether to diol ta kes place efficiently with LAH. It has been proposed that the reaction proceeds via intramolecular hydride transfer from the alkoxy aluminiu m hydride. In order to substantiate this, reduction of TBDMS ether wit h LAH in a variety of substrates was studied.