Isatin (Indole-2, 3-dione) inhibits natriuretic peptide-induced hyperthermia in rats

The effects of an endogenous indole, isatin (indole-2,3-dione), on the hype rthermia induced by atrial natriuretic peptide (ANP-28), brain natriuretic peptide (BNP-32), and C-type natriuretic peptide (CNP-22) were investigated in rats. Intracerebroventricular administration of each peptide in a dose of 1 mu g caused elevations in colon temperature 30 and 60 min after inject ion. An intraperitoneal (i.p.) injection of isatin (50 mg/kg) abolished the natriuretic peptide-induced hyperthermia. These data reinforce the possibl e involvement of natriuretic peptides in thermoregulatory processes in the central nervous system, and suggest that isatin might counteract their hype rthermic effect in vivo. (C) 2000 Elsevier Science Inc. All rights reserved .