CCK/dopamine interactions in Fawn-Hooded and Wistar-Kyoto rat brain

The aim of this study was to compare the actions of CCK neuropeptides withi n the nucleus accumbens (N.Acc) of alcohol preferring (Fawn-Hooded, FH) and alcohol nonpreferring (Wistar-Kyoto, WKY) rats. CCK-8S (30-300 nM) facilit ated the K+ stimulated release of [H-3]dopamine (DA) from N.Acc prisms in b oth rat strains, whereas CCK-4 (30 nM-1 mu M) caused a significant decrease of evoked [H-3]DA in the FH rat only. A scattered distribution of CCK-A an d -B receptor immunopositive varicose fibers were visualized throughout the N.Acc of both rat strains along with a topographic distribution of CCK rec eptor positive cells throughout the ventral mesencephalon. (C) 2000 Elsevie r Science Inc. All rights reserved.