Effects of oral casokefamide on plasma levels, tolerance, and intestinal transit in man

Food-derived opioid peptides such as beta-casomorphins are of interest for treatment of chronic diarrhea. The beta-casomorphin analog casokefamide was administered orally at doses of 5.5, 8.0, and 16.0 mg to 10 healthy male v olunteers, respectively. Dose-dependent increases of plasma levels with a m aximum of 350 fmol/l were determined. No side-effects due to casokefamide h as been observed. In comparison to placebo, casokefamide showed a trend tow ard prolongation of oro-caecal transit time. Orally applied casokefamide is well tolerated and may represent a useful tool for treatment of diarrhea i n the future. (C) 2000 Elsevier Science Inc. All rights reserved.