Synthesis and antioxidant properties of some new flavone derivatives on lipid peroxidation in the rat liver

Authors
Tuncbilek, M Ayhan-Kilcigil, G Ertan, R Can-Eke, B Iscan, M
Citation
M. Tuncbilek et al., Synthesis and antioxidant properties of some new flavone derivatives on lipid peroxidation in the rat liver, PHARMAZIE, 55(5), 2000, pp. 359-361
Citations number
21
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMAZIE
ISSN journal
00317144 → ACNP
Volume
55
Issue
5
Year of publication
2000
Pages
359 - 361
Database
ISI
SICI code
0031-7144(200005)55:5<359:SAAPOS>2.0.ZU;2-Y
Abstract
A series of 2'-, 3'-, 4'- and 6-substituted flavone derivatives was synthes ized and their in vitro effects on rat liver microsomal NADPH-dependent lip id peroxidation (LP) levels were determined. Retinoic acid, at 10(-4) M con centration, decreased the LP level by about 34%. A significant decrease in male liver microsomal LP level was noted for the compounds 3d, 1a, 3b and 4 b at a concentration of 10(-4) M (100%, 95%, 75% and 62%, respectively).