Working in the context of a Lorentz-violating extension of the standard mod
el we show that estimates of Lorentz symmetry violation extracted from ultr
a-high-energy cosmic rays beyond the Greisen-Kuzmin-Zatsepilk (GZK) cutoff
allow for setting bounds on parameters of that extension. Furthermore, we a
rgue that a correlated measurement of the difference in the arrival time of
gamma-ray photons and neutrinos emitted from active galactic nuclei or gam
ma-ray bursts may provide a signature of possible violation of Lorentz symm
etry. We have found that this time delay is energy independent; however it
has a dependence on the chirality of the particles involved. We also briefl
y discuss the known settings where the mechanism for spontaneous Violation
of Lorentz symmetry in the context of string/M-theory may take place.