A cytotoxic diterpene from Alomia myriadenia

Authors
Zani, CL Alves, TMA Queiroz, R Fontes, ES Shin, YG Cordell, GA
Citation
Cl. Zani et al., A cytotoxic diterpene from Alomia myriadenia, PHYTOCHEM, 53(8), 2000, pp. 877-880
Citations number
10
Categorie Soggetti
Agricultural Chemistry","Animal & Plant Sciences
Journal title
PHYTOCHEMISTRY
ISSN journal
00319422 → ACNP
Volume
53
Issue
8
Year of publication
2000
Pages
877 - 880
Database
ISI
SICI code
0031-9422(200004)53:8<877:ACDFAM>2.0.ZU;2-N
Abstract
An extract of the aerial palls from Alomia myriadenia Schultz-Bip. ex Baker (Asteracrae) showed significant cytotoxicity against a panel of human canc er cell lines in a screening of extracts from Brazilian Atlantic Forest pla nt species. Employing a bioassay-linked HPLC-electrospray/MS method, follow ed by semi-preparative HPLC, the active component was isolated and characte rized as a mixture of epimers of the labdane diterpene 12S,16-dihydroxy-ent -labda-7,13-dien-15,16-olide. (C) 2000 Elsevier Science Ltd. All rights res erved.