Suspicion of deep venous thrombosis (DVT) is a common reason for acute medi
cal admission. The clinical diagnosis is difficult, and thus significant nu
mbers are investigated and found to be normal. Provision of 24-h radiology
is costly, and there may be a delay in investigation. We assessed computer-
assisted venous occlusion plethysmography as a screening test for DVT, comp
ared with standard radiology. The test has the advantage of being performed
on the ward and if reliable would significantly reduce the number of radio
logical investigations required. We enrolled 215 consecutive patients prese
nting with the possible diagnosis of DVT, of whom 144 had technically adequ
ate plethysmography results. Plethysmography had a sensitivity of 96% (95 %
CI 88-99%) and a negative predictive value of 97% (95 % CI 91-99%). Patien
ts excluded because of technically inadequate results were older (by a mean
7 years, p=0.003). Computer-assisted venous occlusion plethysmography is a
non-invasive method of rapidly screening for DVT which may be safely used
as an initial screening test. The test is less useful in older patients, or
patients unable to keep still for a period of 2 min.