Application of 4-(2-carbazoylpyrrolidin-1-yl)-7-(N,N-dimethyl aminosulphonyl)-2, 1, 3-benzoxadiazole and 4-(2-carbazoylpyrrolidin-1-yl)-7 nitro 2,1,3-benzoxadiazole for the analysis of arylpropionic acids by high performanceliquid chromatography

Authors
Al-Kindy, S
Citation
S. Al-kindy, Application of 4-(2-carbazoylpyrrolidin-1-yl)-7-(N,N-dimethyl aminosulphonyl)-2, 1, 3-benzoxadiazole and 4-(2-carbazoylpyrrolidin-1-yl)-7 nitro 2,1,3-benzoxadiazole for the analysis of arylpropionic acids by high performanceliquid chromatography, QUIM ANAL, 19(1), 2000, pp. 57-59
Citations number
12
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
QUIMICA ANALITICA
ISSN journal
02120569 → ACNP
Volume
19
Issue
1
Year of publication
2000
Pages
57 - 59
Database
ISI
SICI code
0212-0569(2000)19:1<57:AO4A>2.0.ZU;2-I
Abstract
4-(2-Carbazoylpyrrolidin-1-yl)-l-(N,N-dimethylaminosulphonyl)-l 1,3-benzoxa diazole (DBD-ProCZ) and 4-(2-carbazoylpyrolidin-1-yl)-7-nitro-2,1,3-benzoxa diazole (NBD-ProCZ) have been used for the separation of non-steroidal anti -inflammatory drugs (NSAIDS) by high performance liquid chromatography (HPL C) with fluorescence detection. The reagents react with the carboxylic acid moiety of the drug at room temperature in the presence of activation agent s, 2,2(-dipridyl disulfide (DPDS) and triphenylphosphine (TPP), to produce highly fluorescent derivatives. The detection limit was in the picomole ran ge.