Soluble polymer-supported synthesis of a benzimidazole library

Authors
Chi, YC Sun, CM
Citation
Yc. Chi et Cm. Sun, Soluble polymer-supported synthesis of a benzimidazole library, SYNLETT, (5), 2000, pp. 591-594
Citations number
27
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
5
Year of publication
2000
Pages
591 - 594
Database
ISI
SICI code
0936-5214(200005):5<591:SPSOAB>2.0.ZU;2-P
Abstract
The synthesis of benzimidazole 1 using a liquid phase approach is described . Aromatic substitution of immobilized o-fluoronitrobenzene 2 with various amines to o-nitroaniline derivatives 3 is carried out in methylene chloride . Reduction of the aromatic nitro group, followed by subsequent cyclization /elimination gives the benzimidazole skeleton. The crude library members ob tained are of high yields and chemical purities after cleavage.