A convenient dehydration procedure for the synthesis of enantiomerically pure cyanohydrins

Authors
Aquino, F Pauling, H Walther, W Plattner, DA Bonrath, W
Citation
F. Aquino et al., A convenient dehydration procedure for the synthesis of enantiomerically pure cyanohydrins, SYNTHESIS-S, (5), 2000, pp. 731-737
Citations number
28
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
5
Year of publication
2000
Pages
731 - 737
Database
ISI
SICI code
0039-7881(200005):5<731:ACDPFT>2.0.ZU;2-2
Abstract
Starting from protected alpha-hydroxy amides, cyanohydrins (alpha-hydroxy n itriles) are obtained through dehydration by cyanuric chloride/DMF in excel lent yield. The advantages of the procedure are the extremely mild reaction conditions that prevent racemization.