Palladium-catalyzed cyanation reactions of aryl chlorides

Authors
Jin, FQ Confalone, PN
Citation
Fq. Jin et Pn. Confalone, Palladium-catalyzed cyanation reactions of aryl chlorides, TETRAHEDR L, 41(18), 2000, pp. 3271-3273
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
18
Year of publication
2000
Pages
3271 - 3273
Database
ISI
SICI code
0040-4039(20000429)41:18<3271:PCROAC>2.0.ZU;2-5
Abstract
We have discovered an efficient cyanation of aryl chlorides which employs P d-2(dba)(3), dppf and Zn as the catalyst and Zn(CN)(2) as the cyanide sourc e. Both electron-deficient and electron-rich aryl chlorides are effectively cyanated under these conditions. This discovery represents the first succe ssful palladium-catalyzed cyanation of both electron-deficient and electron -rich aryl chlorides. (C) 2000 DuPont Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights reserved.