Synthesis of lipidic tamoxifen

Citation
Mr. Lashley et Mh. Nantz, Synthesis of lipidic tamoxifen, TETRAHEDR L, 41(18), 2000, pp. 3295-3298
Citations number
25
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
18
Year of publication
2000
Pages
3295 - 3298
Database
ISI
SICI code
0040-4039(20000429)41:18<3295:SOLT>2.0.ZU;2-U
Abstract
We describe a general method for elaboration of the ethyl sidechain of tamo xifen and its primary 4-hydroxy metabolite. Novel lipidic tamoxifen and a f unctionalized B-ring analog were synthesized from a common stilbene oxide i ntermediate for potential liposomal applications including estrogen recepto r targeting. (C) 2000 Elsevier Science Ltd. All rights reserved.