Synthesis of 5(20)deoxydocetaxel, a new active docetaxel analogue

Authors
Dubois, J Thoret, S Gueritte, F Guenard, D
Citation
J. Dubois et al., Synthesis of 5(20)deoxydocetaxel, a new active docetaxel analogue, TETRAHEDR L, 41(18), 2000, pp. 3331-3334
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
18
Year of publication
2000
Pages
3331 - 3334
Database
ISI
SICI code
0040-4039(20000429)41:18<3331:SO5ANA>2.0.ZU;2-Y
Abstract
5(20)Deoxydocetaxel was prepared from 13-oxo-10-deacetyl baccatin III. This compound is the first docetaxel analogue with a modified D-ring which is a s active as paclitaxel on microtubules. (C) 2000 Elsevier Science Ltd. All rights reserved.