Hybrids of macrolides and nucleobases or nucleosides

Citation
Am. Costa et J. Vilarrasa, Hybrids of macrolides and nucleobases or nucleosides, TETRAHEDR L, 41(18), 2000, pp. 3371-3375
Citations number
27
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
18
Year of publication
2000
Pages
3371 - 3375
Database
ISI
SICI code
0040-4039(20000429)41:18<3371:HOMANO>2.0.ZU;2-B
Abstract
A few examples of hybrids/conjugates/chimeras of erythromycin A derivatives and nucleobases (uracil and thymine) or thymidine-derived nucleosides are reported. Linkers and reaction conditions have been investigated to avoid t he degradation of the macrolide moiety (glycoside hydrolysis, ring cleavage , dehydration, etc.). (C) 2000 Elsevier Science Ltd. All rights reserved.