A few examples of hybrids/conjugates/chimeras of erythromycin A derivatives
and nucleobases (uracil and thymine) or thymidine-derived nucleosides are
reported. Linkers and reaction conditions have been investigated to avoid t
he degradation of the macrolide moiety (glycoside hydrolysis, ring cleavage
, dehydration, etc.). (C) 2000 Elsevier Science Ltd. All rights reserved.