Novel synthesis of 2-thiazolines

Authors
Fernandez, X Fellous, R Dunach, E
Citation
X. Fernandez et al., Novel synthesis of 2-thiazolines, TETRAHEDR L, 41(18), 2000, pp. 3381-3384
Citations number
25
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
18
Year of publication
2000
Pages
3381 - 3384
Database
ISI
SICI code
0040-4039(20000429)41:18<3381:NSO2>2.0.ZU;2-X
Abstract
The synthesis of a series of 2-thiazolines was carried out under mild condi tions from the corresponding thiazolidines, by a Ru-catalyzed/TBHP oxidatio n reaction conditions. The reaction was chemoselective towards the amine-im ine oxidation and was also regioselective, affording the unsaturation at th e 2-position of the heterocycle, even with thiazolidine substrates bearing ester groups at the 4-position. (C) 2000 Elsevier Science Ltd. All rights r eserved.