G. Vidari et al., TiCl14 promoted reaction of aldehydes with 1,5-dienyl allylsilanes: addition accompanied by cyclization, TETRAHEDR L, 41(18), 2000, pp. 3471-3474
TiCl4 readily promotes the addition of 1,5-dienyl allylsilanes to aliphatic
aldehydes with concomitant cyclization to afford 1,3-cis-disubstituted met
hylenecyclohexanes with remarkable stereoselectivity. The trimethylsilyl gr
oup exerts a strong activating and directing influence on the regioselectiv
ity and stereoselectivity of this biomimetic cyclization. (C) 2000 Elsevier
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