Convenient synthesis of protected primary amines from nitriles

Authors
Caddick, S Haynes, AKD Judd, DB Williams, MRV
Citation
S. Caddick et al., Convenient synthesis of protected primary amines from nitriles, TETRAHEDR L, 41(18), 2000, pp. 3513-3516
Citations number
26
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
18
Year of publication
2000
Pages
3513 - 3516
Database
ISI
SICI code
0040-4039(20000429)41:18<3513:CSOPPA>2.0.ZU;2-B
Abstract
Investigations into the use of nickel chloride and sodium borohydride for t he reduction of nitriles showed the secondary amine dimers to be the major products under normal conditions. The addition of a suitable trapping agent , such as di-tert-butyl dicarbonate, allowed the isolation of the protected primary amines. (C) 2000 Published by Elsevier Science Ltd. All rights res erved.