S. Drioli et al., ASYMMETRIC RESOLUTION OF DIASTEREOMERIC 4-ETHOXYCARBONYL-5-PENTYL-GAMMA-BUTYROLACTONES BY CRUDE PLE-MEDIATED HYDROLYSIS, Journal of molecular catalysis. B, Enzymatic, 3(1-4), 1997, pp. 203-207
Chemical reduction of diethyl 1-oxo-hexylsuccinate resulted in the for
mation of the corresponding cis and trans disubstituted gamma-butyrola
ctones. Both racemic diastereomers were resolved by means of lipolytic
enzymes leading to the precursors of interesting natural products suc
h as (-)-methylenolactocin and (-)-phaseolinic acid.