ASYMMETRIC RESOLUTION OF DIASTEREOMERIC 4-ETHOXYCARBONYL-5-PENTYL-GAMMA-BUTYROLACTONES BY CRUDE PLE-MEDIATED HYDROLYSIS

Authors
DRIOLI S FELLUGA F FORZATO C NITTI P PITACCO G VALENTIN E
Citation
S. Drioli et al., ASYMMETRIC RESOLUTION OF DIASTEREOMERIC 4-ETHOXYCARBONYL-5-PENTYL-GAMMA-BUTYROLACTONES BY CRUDE PLE-MEDIATED HYDROLYSIS, Journal of molecular catalysis. B, Enzymatic, 3(1-4), 1997, pp. 203-207
Citations number
18
Categorie Soggetti
Chemistry Physical
Journal title
Journal of molecular catalysis. B, Enzymatic → ACNP
ISSN journal
13811177
Volume
3
Issue
1-4
Year of publication
1997
Pages
203 - 207
Database
ISI
SICI code
1381-1177(1997)3:1-4<203:AROD4>2.0.ZU;2-F
Abstract
Chemical reduction of diethyl 1-oxo-hexylsuccinate resulted in the for mation of the corresponding cis and trans disubstituted gamma-butyrola ctones. Both racemic diastereomers were resolved by means of lipolytic enzymes leading to the precursors of interesting natural products suc h as (-)-methylenolactocin and (-)-phaseolinic acid.