Assessment of liver disease and biochemical and immunological markers in Swedish blood donors with isolated GB virus C/hepatitis G virus viremia

Objective: To investigate signs of liver disease, and biochemical and immun ological markers in blood donors with isolated GBV-C/HGV viremia, Methods: Eighteen donors with isolated GBV-C/HGV viremia were followed up 3-5 years after initial identification. Testing for GBV-C/HGV RNA, GBV-C/HGV-E2 antib odies and a range of biochemical and immunological tests was performed. Thi rteen donors consented to liver biopsy. Results: Twelve donors remained GBV -C/HGV viremic at follow-up. Five donors had developed E2 antibodies. Liver biopsies revealed mild portal inflammatory lesions in 6/11 individuals wit h persistent viremia, and steatosis in 10/13 biopsied donors. Conclusion: S teatosis and mild portal inflammatory lesions were found in liver biopsies from several blood donors with isolated GBV-C/HGV viremia. Copyright (C) 20 00 S. Karger AG, Basel.