Km. Carpenter et al., FACIAL SKELETAL GROWTH AFTER ENDOSCOPIC SINUS SURGERY IN THE PIGLET MODEL, American journal of rhinology, 11(3), 1997, pp. 211-217
This study examined the effects of varying degrees of endoscopic sinus
surgery on the growing midface and snout in pigs. In this randomized,
controlled experiment, thirty 40-60-pound pigs were placed in five ex
perimental groups: (1) unilateral uncinectomy; (2) bilateral uncinecto
my; (3) unilateral uncinectomy, anterior ethmoidectomy, maxillary antr
ostomy; (4) bilateral uncinectomy, anterior ethmoidectomy, maxillary a
ntrostomy; (5) unoperated controls. Animals were killed after 3 months
and growth wets assessed, according to linear and spatial measurement
s of multiple craniofacial regions. Euclidean distance matrix analysis
showed significant restrictive shape alterations in a linear-fashion
in groups 1-4 (p < .05). These alterations occurred in the surgical fi
eld of the snout, midsnout, and maxilla. Endoscopic sinus surgery caus
es significant restrictive effects in the growing porcine facial skele
ton.