A systematic survey of 13 randomized trials of nonsteroidal anti-inflammatory drugs for the prevention of heterotopic bone formation after major hip surgery
Bc. Neal et al., A systematic survey of 13 randomized trials of nonsteroidal anti-inflammatory drugs for the prevention of heterotopic bone formation after major hip surgery, ACT ORTH SC, 71(2), 2000, pp. 122-128
Citations number
28
Categorie Soggetti
Ortopedics, Rehabilitation & Sport Medicine","da verificare
We performed a systematic survey of randomized trials to determine the effe
cts of perioperative NSAIDs on the occurrence of heterotopic bone formation
, gastrointestinal side-effects and long-term clinical outcomes after major
hip surgery. 13 trials involving 4,129 individuals were identified. Overal
l, in 12 small trials of medium-to-high-dose regimens, there was a 57% redu
ction (95% confidence interval 51%-63%) in the risk of heterotopic bone for
mation. The results of one large trial of low-dose aspirin differed markedl
y (2% reduction (95% CI 12% reduction to 15% increase)). The NSAID regimens
studied had no definite effect on gastrointestinal complications, and data
about the effects of NSAIDs on pain and function were too few,and too inco
mpletely reported, to draw conclusions about their effects on these outcome
s. Routine prophylaxis against heterotopic bone formation with NSAIDs may b
e a useful adjuvant therapy for patients undergoing major hip surgery, but
the overall balance of risks and benefits requires assessment in a large-sc
ale randomized trial.