Gastroesophageal reflux disease.(GERD) is a chronic acid-peptic disorder th
at is the combined result of several factors: 1) the lack of gastrointestin
al motility coordination, 2) the failure of the lower esophageal sphincter
to prevent reflux, and 3) the caustic nature of the gastric refluxate. Alth
ough GERD is very common, only a small fraction of sufferers consult a phys
ician regarding their problem. This disease has a tremendous impact on both
quality of life and overall health. If untreated, GERD can result in many
serious complications, including erosive esophagitis, Barrett's esophagus,
and esophageal adenocarcinoma. Because the caustic nature of the refluxate
is a direct cause of esophageal damage, the cornerstone of GERD therapy is
gastric acid suppression.