Heterogeneity in Paget disease of the bone

Authors
Nance, MA Nuttall, FQ Econs, MJ Lyles, KW Viles, KD Vance, JM Pericak-Vance, MA Speer, MC
Citation
Ma. Nance et al., Heterogeneity in Paget disease of the bone, AM J MED G, 92(5), 2000, pp. 303-307
Citations number
11
Categorie Soggetti
Molecular Biology & Genetics
Journal title
AMERICAN JOURNAL OF MEDICAL GENETICS
ISSN journal
01487299 → ACNP
Volume
92
Issue
5
Year of publication
2000
Pages
303 - 307
Database
ISI
SICI code
0148-7299(20000619)92:5<303:HIPDOT>2.0.ZU;2-B
Abstract
Paget disease of the bone is a common skeletal disorder. Recently, a gene f or Paget disease was localized to 18q with subsequent evidence for linkage heterogeneity. We report the identification and clinical characterization o f a large pedigree of Paget disease and demonstrate that the Paget disease gene in this pedigree is not linked to the region on 18q, thus confirming l inkage heterogeneity. Am J. Med. Genet. 92:303-307, 2000. (C) 2000 Wiley-Li ss, Inc.