The role of amniotic fluid interleukin-6, and cell adhesion molecules, intercellular adhesion molecule-1 and leukocyte adhesion molecule-1, in intra-amniotic infection

Citation
Cd. Hsu et al., The role of amniotic fluid interleukin-6, and cell adhesion molecules, intercellular adhesion molecule-1 and leukocyte adhesion molecule-1, in intra-amniotic infection, AM J REPROD, 43(5), 2000, pp. 251-254
Citations number
15
Categorie Soggetti
Immunology
Journal title
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
ISSN journal
10467408 → ACNP
Volume
43
Issue
5
Year of publication
2000
Pages
251 - 254
Database
ISI
SICI code
1046-7408(200005)43:5<251:TROAFI>2.0.ZU;2-M
Abstract
PROBLEM: To determine amniotic fluid concentrations and correlations of int erleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1), and leukocyt e adhesion molecule-1 (LAM-1) in patients with and without intra-amniotic i nfection. METHOD OF STUDY: Fourteen specimens with intra-amniotic infection and 45 wi thout intra-amniotic infection were studied. Intra-amniotic infection was d efined as the presence of a positive amniotic fluid culture. Amniotic fluid IL-6, ICAM-1, and LAM-1 levels were determined by an enzyme-linked immunoa ssay, and normalized by amniotic fluid creatinine levels. RESULTS: Amniotic fluid concentrations of IL-6 and LAM-1 were significantly higher in patients with than without intra-amniotic infection. However, am niotic fluid ICAM-1 concentrations were not significantly different between two groups. Amniotic fluid IL-6, LAM-1, and ICAM-1 were positively correla ted. CONCLUSIONS: Our data indicate that amniotic fluid IL-6 is significantly as sociated with an increased adhesion molecule expression in intra-amniotic i nfection. However, LAM-1 plays a more important role than ICAM-1 in intra-a mniotic infection.