The role of amniotic fluid interleukin-6, and cell adhesion molecules, intercellular adhesion molecule-1 and leukocyte adhesion molecule-1, in intra-amniotic infection
Cd. Hsu et al., The role of amniotic fluid interleukin-6, and cell adhesion molecules, intercellular adhesion molecule-1 and leukocyte adhesion molecule-1, in intra-amniotic infection, AM J REPROD, 43(5), 2000, pp. 251-254
PROBLEM: To determine amniotic fluid concentrations and correlations of int
erleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1), and leukocyt
e adhesion molecule-1 (LAM-1) in patients with and without intra-amniotic i
nfection.
METHOD OF STUDY: Fourteen specimens with intra-amniotic infection and 45 wi
thout intra-amniotic infection were studied. Intra-amniotic infection was d
efined as the presence of a positive amniotic fluid culture. Amniotic fluid
IL-6, ICAM-1, and LAM-1 levels were determined by an enzyme-linked immunoa
ssay, and normalized by amniotic fluid creatinine levels.
RESULTS: Amniotic fluid concentrations of IL-6 and LAM-1 were significantly
higher in patients with than without intra-amniotic infection. However, am
niotic fluid ICAM-1 concentrations were not significantly different between
two groups. Amniotic fluid IL-6, LAM-1, and ICAM-1 were positively correla
ted.
CONCLUSIONS: Our data indicate that amniotic fluid IL-6 is significantly as
sociated with an increased adhesion molecule expression in intra-amniotic i
nfection. However, LAM-1 plays a more important role than ICAM-1 in intra-a
mniotic infection.